Take I-85 North toward Greenville.
Immediately after the SC state line, exit to the right to take SC Highway 11 (Cherokee Foothills Scenic Highway).
Go past Seneca, Walhalla, Pickins, and Table Rock State Park.
A few miles past Table Rock State Park, Hwy 11 merges with Hwy 276.
Bear to the right on what is now Hwy 11/276 toward Marietta, SC
Go about 4 miles and look for the F-Mart store on the left.
After passing the F-Mart, turn left onto River Falls Road, where sign points to Jones Gap State Park.
Follow River Falls Road for 6 miles. Pass Gap Creek Road on the right.
Go 1/10 mile more to River Falls Lodge Drive on the right.
Turn right and the lodge is on the right

Here are Google driving directions